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J Gen Virol 70 (1989), 467-472; DOI 10.1099/0022-1317-70-2-467
© 1989 Society for General Microbiology
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Destruction of Lymphocytes by a Virulent Avian Influenza A Virus

Hana Van Campen, Bernard C. Easterday and Virginia S. Hinshaw

Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53706, U.S.A.

Infection of chickens by a virulent avian influenza A virus, A/turkey/Ont/7732/66 (H5N9), was associated with a severe lymphopenia. High titres of infectious virus were found in lymphoid tissues early in infection and were accompanied by severe damage to the lymphocyte populations as demonstrated by histopathological examination. Non-lymphoid cell populations in these tissues were unaffected, as were other organs examined. The viral nucleoprotein was localized by immunoperoxidase staining to lymphocytes in affected tissues early in infection.

Keywords: influenza virus, lymphoid destruction, pathogenesis

Received 19 January 1988; accepted 13 October 1988.


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