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Identification of Papillomaviral DNA Sequences in Hairless Mouse Tumours Induced by Ultraviolet Irradiation

¹ Department of Microbiology, University of Western Australia, Nedlands, Western Australia 6009
² Department of Veterinary Pathology, University of Sydney, Australia
and³ Deutsches Krebsforschungszentrum, Heidelberg, F.R.G.

Papillomas, carcinomas in situ and squamous cell carcinomas were induced using ultraviolet irradiation in the hairless mouse strain Mus musculus HRA/Skh. DNA extracted from biopsies was examined using Mastomys natalensis papillomaviral DNA as a hybridization probe at reduced stringency. Sequences homologous to the probe were detected in 16 of 24 papillomas, five of five carcinomas in situ and six of 38 squamous cell carcinomas. A number of tumour DNAs (16/33) also hybridized with mixed DNAs of human papillomavirus types 11, 13, 16 and 18 at reduced stringency. This suggests a role for the hairless mouse as a laboratory model for the study of the involvement of papillomaviruses in malignant transformations.

Keywords: papillomavirus, hairless mouse, cancer

Received 9 August 1988; accepted 5 December 1988.