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J Gen Virol 70 (1989), 893-900; DOI 10.1099/0022-1317-70-4-893
© 1989 Society for General Microbiology
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Characterization of IgG Fc Receptors Induced by Human Cytomegalovirus

Xu-Bin, Tsugiya Murayama, Keiko Ishida and Toru Furukawa

Department of Microbiology, Kanazawa Medical University, Uchinada, Ishikawa, Japan 920-02

Immunoglobulin G Fc receptors (IgG FcRs) induced by human cytomegalovirus (HCMV) were isolated from solubilized HCMV-infected cell extracts by IgG affinity chromatography and analysed by Western blotting using 125I-labelled human IgG and Fc. FcR species of Mr 130K, 65K, 50K and 38K were found to mediate the binding of IgG. The 130K and 65K FcRs were also detected on HCMV virions. All four FcRs were reactive with a murine monoclonal antibody to herpes simplex virus glycoprotein E. Anti-HCMV antibodies markedly inhibited the binding of 125I-labelled human IgG Fc to the 130K and 50K species but inhibited to a lesser extent the binding to the 65K FcR.

Keywords: cytomegalovirus, human, Fc receptors, IgG

Received 12 August 1988; accepted 18 November 1988.


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