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Influenza Virus-specific T Cells Lead to Early Interferon in Lungs of Infected Hosts: Development of a Sensitive Radioimmunoassay

¹ Division of Immunology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA
and² Division of Immunology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN7 3QG, U.K.

A sensitive immunoradiometric assay for murine interferon (MuIFN-) has been developed and used reproducibly to measure low levels of MuIFN- in lung lavage samples from influenza-infected mice. In control infected mice, IFN- peaked on day 6, but transfer of virus-specific cytotoxic T cells or T helper cells, which reduced virus replication in vivo in infected hosts, resulted in an earlier peak on day 4.

Keywords: interferon (MuIFN-), influenza virus, T cells

Received 18 October 1988; accepted 6 December 1988.

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