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1 Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
and2 Department of Pathology
and3 Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195, U.S.A.
Primary human epithelial cells were transfected with a subgenomic fragment of DNA cloned from a cervical carcinoma, containing the putative transforming genes E6 and E7 from the human papillomavirus type 16 prototype. Several immortalized cell lines were generated, all retaining tumour DNA and expressing the viral genes, suggesting that either one or both of these genes is sufficient for the immortalization of primary human genital keratinocytes.
Keywords: HPV, cervical carcinoma DNA, immortalization
Received 1 November 1988;
accepted 3 January 1989.
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