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Effect of Interferon on the Accumulation of RNA Transcripts of Genes Coding for Cellular and Viral Proteins

Department of Biology, Aristotelian University of Thessaloniki, 54006 Thessaloniki, Greece

Using plasmids containing sequences complementary to the genes that code for oligo-2',5'-adenylate synthetase, actin and H4 histone, we have shown that although interferon does not affect the accumulation of RNA transcripts of the actin and H4 histone genes, it activates the accumulation of RNA transcripts of the oligo-2',5'-adenylate synthetase gene. However, interferon inhibits the accumulation of RNA transcripts of simian virus 40 (SV40) genes in SV40-infected cells.

Keywords: 2-5AS, SV40, interferon(HuIFN-)

Received 1 July 1988; accepted 3 January 1989.