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J Gen Virol 70 (1989), 1605-1608; DOI 10.1099/0022-1317-70-6-1605
© 1989 Society for General Microbiology
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Antibody-dependent Enhancement of Yellow Fever and Japanese Encephalitis Virus Neurovirulence

E. A. Gould{dagger} and A. Buckley{dagger}

Arbovirus Research Unit, 395 Hatfield Road, St Albans, Hertfordshire AL4 0XQ, U.K.

Antibody-dependent enhancement of yellow fever virus neurovirulence, as measured by a reduction in the average survival time of groups of mice, was demonstrated with wild-type or vaccine strains of yellow fever virus and with Japanese encephalitis virus using intraperitoneally administered monoclonal antibodies specific for the viral E glycoprotein of yellow fever virus. Enhancement of virulence could be induced by neutralizing, non-neutralizing or protective antibodies if the virus was allowed to establish a productive infection in the mouse brain before the antibody was administered. The implications of antibody-dependent enhancement in flaviviruses are discussed.

Keywords: yellow fever, Japanese encephalitis, immune enhancement

{dagger} Present address: Natural Environmental Research Council, Institute of Virology, Mansfield Road, Oxford OX1 3SR, U.K.

Received 10 October 1988; accepted 6 March 1989.


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