| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 AFRC and MRC Neuropathogenesis Unit, Institute for Animal Health, West Mains Road, Edinburgh EH9 3JF
and2 MRC Radiobiology Unit, Chilton, Didcot, Oxfordshire, OX11 0RD, U.K.
263K is the most widely used strain of agent in scrapie research because it produces very short incubation periods in golden hamsters and exceptionally high infectivity titres in clinically affected brain. 263K is also remarkable in having a very low pathogenicity for mice. Evidence is presented that 263K originated as a mutant that was strongly selected on passage in hamsters. Seven new passage lines have been established in hamsters using well characterized strains of mouse scrapie representing the ‘drowsy goat’ and SSBP/1 families of scrapie strains, and one natural scrapie source. Considerable differences between scrapie strains were found in hamsters using incubation period criteria alone. There was evidence that the parent strain of 263K might be 79V or a strain like it in the ‘drowsy goat’ family. Four of the hamster passage lines were established from scrapie strains that had been cloned in mice. Reisolates in mice were compared with original strains. By the criteria used, two of the reisolates were the same as the original strains. Two others were mutants with incubation periods longer than those of their parental strains but the mutants were different from one another. It is concluded that passage between mice and hamsters can select mutants that would otherwise be lost but there is also clear evidence that the genotypic identity of some scrapie strains is preserved on passage between different host species. These findings are important in the search for the putative nucleic acid genome of the scrapie agent.
Keywords: scrapie, interspecies transmission, genome
Present address: SARDAS, 27 Laverockdale Park, Edinburgh, EH13 0QE, U.K.
Received 21 November 1988;
accepted 10 April 1989.
This article has been cited by other articles:
|
|
 |
|
  N. Makarava and I. V. Baskakov The Same Primary Structure of the Prion Protein Yields Two Distinct Self-propagating States J. Biol. Chem., June 6, 2008; 283(23): 15988 - 15996. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J D Bailey, J G Berardinelli, T E Rocke, and R A Bessen Prominent pancreatic endocrinopathy and altered control of food intake disrupt energy homeostasis in prion diseases J. Endocrinol., May 1, 2008; 197(2): 251 - 263. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Cronier, V. Beringue, A. Bellon, J.-M. Peyrin, and H. Laude Prion Strain- and Species-Dependent Effects of Antiprion Molecules in Primary Neuronal Cultures J. Virol., December 15, 2007; 81(24): 13794 - 13800. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Makarava, C.-I Lee, V. G. Ostapchenko, and I. V. Baskakov Highly Promiscuous Nature of Prion Polymerization J. Biol. Chem., December 14, 2007; 282(50): 36704 - 36713. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Bartz, M. L. Kramer, M. H. Sheehan, J. A. L. Hutter, J. I. Ayers, R. A. Bessen, and A. E. Kincaid Prion Interference Is Due to a Reduction in Strain-Specific PrPSc Levels J. Virol., January 15, 2007; 81(2): 689 - 697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Atarashi, V. L. Sim, N. Nishida, B. Caughey, and S. Katamine Prion strain-dependent differences in conversion of mutant prion proteins in cell culture. J. Virol., August 1, 2006; 80(16): 7854 - 7862. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Piening, R. Nonno, M. Di Bari, S. Walter, O. Windl, U. Agrimi, H. A. Kretzschmar, and U. Bertsch Conversion Efficiency of Bank Vole Prion Protein in Vitro Is Determined by Residues 155 and 170, but Does Not Correlate with the High Susceptibility of Bank Voles to Sheep Scrapie in Vivo J. Biol. Chem., April 7, 2006; 281(14): 9373 - 9384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Thomzig, S. Spassov, M. Friedrich, D. Naumann, and M. Beekes Discriminating Scrapie and Bovine Spongiform Encephalopathy Isolates by Infrared Spectroscopy of Pathological Prion Protein J. Biol. Chem., August 6, 2004; 279(32): 33847 - 33854. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Arjona, L. Simarro, F. Islinger, N. Nishida, and L. Manuelidis Two Creutzfeldt-Jakob disease agents reproduce prion protein-independent identities in cell cultures PNAS, June 8, 2004; 101(23): 8768 - 8773. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Chesebro Introduction to the transmissible spongiform encephalopathies or prion diseases Br. Med. Bull., June 1, 2003; 66(1): 1 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E Bruce TSE strain variation: An investigation into prion disease diversity Br. Med. Bull., June 1, 2003; 66(1): 99 - 108. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. A. H. Wells, S. A. C. Hawkins, A. R. Austin, S. J. Ryder, S. H. Done, R. B. Green, I. Dexter, M. Dawson, and R. H. Kimberlin Studies of the transmissibility of the agent of bovine spongiform encephalopathy to pigs J. Gen. Virol., April 1, 2003; 84(4): 1021 - 1031. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Aucouturier and C. Carnaud The immune system and prion diseases: a relationship of complicity and blindness J. Leukoc. Biol., December 1, 2002; 72(6): 1075 - 1083. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Horiuchi, T. Nemoto, N. Ishiguro, H. Furuoka, S. Mohri, and M. Shinagawa Biological and Biochemical Characterization of Sheep Scrapie in Japan J. Clin. Microbiol., September 1, 2002; 40(9): 3421 - 3426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Bruce, A. Boyle, S. Cousens, I. McConnell, J. Foster, W. Goldmann, and H. Fraser Strain characterization of natural sheep scrapie and comparison with BSE J. Gen. Virol., March 1, 2002; 83(3): 695 - 704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Race, A. Raines, G. J. Raymond, B. Caughey, and B. Chesebro Long-Term Subclinical Carrier State Precedes Scrapie Replication and Adaptation in a Resistant Species: Analogies to Bovine Spongiform Encephalopathy and Variant Creutzfeldt-Jakob Disease in Humans J. Virol., November 1, 2001; 75(21): 10106 - 10112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Brown Regular review: Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease BMJ, April 7, 2001; 322(7290): 841 - 844. [Full Text]
|
|
|
|
 |
|
 D. Peretz, M. R. Scott, D. Groth, R. A. Williamson, D. R. Burton, F. E. Cohen, and S. B. Prusiner Strain-specified relative conformational stability of the scrapie prion protein Protein Sci., April 1, 2001; 10(4): 854 - 863. [Abstract] [Full Text]
|
|
|
|
|
|
F. Lopez Garcia, R. Zahn, R. Riek, and K. Wuthrich NMR structure of the bovine prion protein PNAS, July 18, 2000; 97(15): 8334 - 8339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Qin, D.-S. Yang, Y. Yang, M. A. Chishti, L.-J. Meng, H. A. Kretzschmar, C. M. Yip, P. E. Fraser, and D. Westaway Copper(II)-induced Conformational Changes and Protease Resistance in Recombinant and Cellular PrP. EFFECT OF PROTEIN AGE AND DEAMIDATION J. Biol. Chem., June 16, 2000; 275(25): 19121 - 19131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Bartz, R. A. Bessen, D. McKenzie, R. F. Marsh, and J. M. Aiken Adaptation and Selection of Prion Protein Strain Conformations following Interspecies Transmission of Transmissible Mink Encephalopathy J. Virol., June 15, 2000; 74(12): 5542 - 5547. [Abstract] [Full Text]
|
|
|
|
|
|
T. Sweeney, T. Kuczius, M. McElroy, M. G. Parada, and M. H. Groschup Molecular analysis of Irish sheep scrapie cases J. Gen. Virol., June 1, 2000; 81(6): 1621 - 1627. [Abstract] [Full Text]
|
|
|
|
|
|
M. R. Scott, R. Will, J. Ironside, H.-O. B. Nguyen, P. Tremblay, S. J. DeArmond, and S. B. Prusiner From the Cover: Compelling transgenetic evidence for transmission of bovine spongiform encephalopathy prions to humans PNAS, December 21, 1999; 96(26): 15137 - 15142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Chabry, S. A. Priola, K. Wehrly, J. Nishio, J. Hope, and B. Chesebro Species-Independent Inhibition of Abnormal Prion Protein (PrP) Formation by a Peptide Containing a Conserved PrP Sequence J. Virol., August 1, 1999; 73(8): 6245 - 6250. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. Tan, M. A. Williams, M. K. Khan, H. C. Champion, N. H. Nielsen, and for the Council on Scientific Affairs, American Me Risk of Transmission of Bovine Spongiform Encephalopathy to Humans in the United States: Report of the Council on Scientific Affairs JAMA, June 23, 1999; 281(24): 2330 - 2339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Prusiner Prions PNAS, November 10, 1998; 95(23): 13363 - 13383. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Prusiner Prion Diseases and the BSE Crisis Science, October 10, 1997; 278(5336): 245 - 251. [Abstract] [Full Text]
|
|
|
|
|
|
G. C. Telling, P. Parchi, S. J. DeArmond, P. Cortelli, P. Montagna, R. Gabizon, J. Mastrianni, E. Lugaresi, P. Gambetti, and S. B. Prusiner Evidence for the Conformation of the Pathologic Isoform of the Prion Protein Enciphering and Propagating Prion Diversity Science, December 20, 1996; 274(5295): 2079 - 2082. [Abstract] [Full Text]
|
|
|
|
 |
|
 R Hecker, A Taraboulos, M Scott, K M Pan, S L Yang, M Torchia, K Jendroska, S J DeArmond, and S B Prusiner Replication of distinct scrapie prion isolates is region specific in brains of transgenic mice and hamsters. Genes & Dev., July 1, 1992; 6(7): 1213 - 1228. [Abstract] [PDF]
|
|
|
|
|
|
M. Horiuchi, S. A. Priola, J. Chabry, and B. Caughey Interactions between heterologous forms of prion protein: Binding, inhibition of conversion, and species barriers PNAS, May 23, 2000; 97(11): 5836 - 5841. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
