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Antibody Responses and Protection in Mice Immunized with Herpes Simplex Virus Type 1 Antigen Immune-stimulating Complex Preparations

¹ Department of Virology, Medical School, University of Sheffield, Beech Hill Road, Sheffield S10 2RX
and² National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Hertfordshire EN6 3QG, U.K.

The formation of immune-stimulating complexes (iscoms) obtained by mixing the glycoside Quil A with an antigen preparation derived from herpes simplex virus type 1 (HSV-1)-infected cell cultures using a zwitterionic detergent is described. The HSV-1 antigen preparation incorporated into iscoms elicited significantly greater antibody responses in mice than the same preparation administered together with aluminium hydroxide gel, and provided complete protection against HSV-1 or HSV-2 lethal, systemic challenge infection in animals given a single dose containing 5 µg of protein. The HSV-1 iscom preparation also provided significant protection in mice against local reactions following challenge with HSV-1 by skin scarification.

Keywords: HSV-1, immune-stimulating complex

Received 3 April 1989; accepted 14 April 1989.