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A Role for Herpes Simplex Virus Type 1 Glycoprotein E in Induction of Cell Fusion

Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35294, U.S.A.

The role of herpes simplex virus type 1 (HSV-1) glycoprotein E (gE) in the induction of multinucleate cell (syncytium) formation was investigated using monoclonal antibodies and a gE deletion mutant, R7023. We found that monoclonal antibodies directed against gE blocked HSV-1-induced syncytium formation in human cells. R7023 also failed to induce syncytium formation in tissue culture cells. The results indicate that gE, in addition to glycoproteins B, D, H and the gene sequence located between 0.732 and 0.745 map units, is involved in cell fusion. Thus, this important biological property appears to be regulated by several HSV-1 gene products.

Keywords: HSV-1, glycoprotein E, fusion

Received 10 November 1988; accepted 10 April 1989.

This article has been cited by other articles:

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