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Gangliosides Influence Experimental Influenza Virus Infection in Mice

¹ Central Institute for Postgraduate Training of Physicians
² D. I. Ivanovsky Institute of Virology
³ Institute of Experimental Cardiology, Cardiology Research Center
and⁴ M. M. Shemyakin Institute of Bioorganic Chemistry of U.S.S.R. Academy of Sciences, Moscow, U.S.S.R.

Influenza virus infection in mice may be either stimulated or partially prevented by certain gangliosides, depending on the experimental conditions employed. When injected prior to virus infection gangliosides increased the mortality rate, whereas preincubation with the virus before infection had a protecting effect. Hybrid mice resistant to influenza virus became highly susceptible to infection after injection of a specific ganglioside whereas the corresponding antiganglioside antiserum protected virus-susceptible mice against infection by the virus. These results are discussed in the light of earlier findings that various gangliosides enhance non-specific binding of influenza virus, whereas gangliosides of the G_T1b and G_D1b type are able to act as specific virus receptors and to promote virus penetration.

Keywords: influenza virus, gangliosides, mortality rate

Received 11 January 1989; accepted 7 June 1989.