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The Polypeptide of M_r 14000 of Porcine Transmissible Gastroenteritis Virus: Gene Assignment and Intracellular Location

AFRC Institute for Animal Health, Compton Laboratory, Compton, near Newbury, Berkshire RG16 0NN, U.K.

Synthetic oligopeptides, corresponding to an amino acid sequence encoded by a potential M_r 9000 product's open reading frame (ORF-4) at the 3' terminus of the transmissible gastroenteritis virus genome, were used to generate rabbit antiserum. These antibodies produced immune complexes with an M_r 14000 (14K) polypeptide in infected cells. The 14K product was shown by immune fluorescence to become associated with the cell nucleus, correlating with the onset of nuclear vacuolation, and suggesting a role in pathogenesis for the ORF-4 gene.

Keywords: TGEV, pathogenesis, nuclear degeneration

Received 5 March 1989; accepted 17 May 1989.

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