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The Effects of 5-Azacytidine, 12-O-Tetradecanoylphorbol 13-acetate and Sodium n-butyrate on Reactivation of Alphaherpesvirus Saimiri from Explant Cultures of Latently Infected Rabbit Dorsal Root Ganglia

D. A. Leib

Department of Medical Microbiology, University of Liverpool, P.O. Box 147, Liverpool L69 3BX, U.K.

The DNA hypomethylating agent 5-azacytidine greatly increased the reactivation of alphaherpesvirus saimiri-1 (HVS) from latently infected rabbit dorsal root ganglia, although it inhibited the virus yield and plaque formation efficiency of HVS in Vero cells. 12-O-Tetradecanoylphorbol 13-acetate (a protein kinase C activator) and sodium n-butyrate both had a stimulating action on replication in Vero cells but did not affect the release of HVS from latently infected rabbit dorsal root ganglia.

Keywords: alphaherpesvirus saimiri, reactivation, dorsal root ganglia

Present address: Laboratory of Tumor Virus Genetics, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, U.S.A.

Received 1 February 1989; accepted 11 May 1989.

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