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Isolation and Characterization of Temperature-sensitive Mutants of Abelson Murine Leukaemia Virus that Exhibit Dissociation among Morphological Transformation, Soft Agar Colony-forming Ability and Tyrosine Kinase Activity

¹ The Third Department of Internal Medicine, Osaka University Medical School, Fukushima-ku, Osaka 553
and² Department of Tumor Virology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565, Japan

Seven temperature-sensitive (ts) mutants of Abelson murine leukaemia virus (A-MuLV) were isolated on the basis of the temperature dependence of their soft agar colony-forming ability. These seven ts mutants exhibited similar characteristics and were not ts for morphological transformation and autophosphorylation of P120^gag-abl protein. The dissociation of the properties of morphology, soft agar colony formation and tyrosine kinase activity might suggest that the v-abl product has more than one primary intracellular target.

Keywords: Abelson MuLV, ts mutants, tyrosine kinase

Received 7 October 1988; accepted 27 April 1989.