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J Gen Virol 71 (1990), 2283-2289; DOI 10.1099/0022-1317-71-10-2283
© 1990 Society for General Microbiology
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Inhibition of the uncoating of bovine enterovirus by short chain fatty acids

N. Ismail-Cassim1, C. Chezzi2 and J. F. E. Newman2

1 Department of Microbiology, Rhodes University, Grahamstown 6140
and2 National Institute for Virology, University of the Witwatersrand, Private Bag X4, Sandringham 2131, South Africa

Short chain fatty acids inhibit the replication of bovine enterovirus but are almost ineffective against poliovirus type 1, coxsackievirus B5, encephalomyocarditis virus and human rhinovirus 1B. Lauric acid binds to bovine enterovirus, thereby stabilizing the virus particle to heat degradation. Fatty acid-bound virions attach to susceptible cells but fail to undergo cell-mediated uncoating. The inhibitory effect is reversible with chloroform and may result from a hydrophobic interaction between the fatty acid and a specific site on the virus particle.

Received 7 February 1990; accepted 4 June 1990.


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