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J Gen Virol 71 (1990), 2467-2469; DOI 10.1099/0022-1317-71-10-2467
© 1990 Society for General Microbiology
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A synthetic peptide elicits antibody reactive with the native duck hepatitis B virus pre-S protein

Yu-Mei Wen, Yong-Yao Xu, Wei Zhang and Ying-Zheng Liu

Department of Microbiology, Shanghai Medical University, Shanghai 200032, People's Republic of China

Synthetic peptides P37-49 and P63-79, derived from the pre-S region of duck hepatitis B virus (DHBV), have been synthesized. Only P37-49 was reactive with rabbit anti-DHBs/pre-S antibodies by radioimmunoprecipitation. Antiserum prepared against P37-47 reacted with a 35K polypeptide of native DHBs/pre-S by immunoblotting. It is concluded that P37-49 (MGQHPAKSMDVRR) mimics one of the epitopes of the DHBV pre-S antigen.

Received 23 May 1990; accepted 21 June 1990.




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