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Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, U.K.
Murine herpesvirus 68 (MHV-68) is a naturally occurring herpesvirus of small free-living rodents. In order to facilitate the molecular characterization of the virus genome, a library of cloned restriction fragments has been produced and restriction enzyme cleavage maps deduced for the enzymes BamHI, EcoRI and HindIII. The MHV-68 genome comprises a region of unique DNA of approximately 118 kbp which is flanked by variable numbers of a 1.23 kb repeat unit. The organization of the MHV-68 genome is, therefore, most similar to that of the lymphotropic 
2 group of herpesviruses which include herpesvirus saimiri and herpesvirus ateles.
Received 5 December 1989;
accepted 22 February 1990.
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H. Adler, M. Messerle, M. Wagner, and U. H. Koszinowski Cloning and Mutagenesis of the Murine Gammaherpesvirus 68 Genome as an Infectious Bacterial Artificial Chromosome J. Virol., August 1, 2000; 74(15): 6964 - 6974. [Abstract] [Full Text]
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B. J. Lee, S. Santee, S. Von Gesjen, C. F. Ware, and S. R. Sarawar Lymphotoxin-alpha -Deficient Mice Can Clear a Productive Infection with Murine Gammaherpesvirus 68 but Fail To Develop Splenomegaly or Lymphocytosis J. Virol., March 15, 2000; 74(6): 2786 - 2792. [Abstract] [Full Text]
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E. T. Clambey, H. W. Virgin IV, and S. H. Speck Disruption of the Murine Gammaherpesvirus 68 M1 Open Reading Frame Leads to Enhanced Reactivation from Latency J. Virol., February 15, 2000; 74(4): 1973 - 1984. [Abstract] [Full Text]
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J. W. Peacock and K. L. Bost Infection of intestinal epithelial cells and development of systemic disease following gastric instillation of murine gammaherpesvirus-68 J. Gen. Virol., February 1, 2000; 81(2): 421 - 429. [Abstract] [Full Text]
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B. M. Dutia, J. P. Stewart, R. A. E. Clayton, H. Dyson, and A. A. Nash Kinetic and phenotypic changes in murine lymphocytes infected with murine gammaherpesvirus-68 in vitro J. Gen. Virol., October 1, 1999; 80(10): 2729 - 2736. [Abstract] [Full Text]
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S. B. Kapadia, H. Molina, V. van Berkel, S. H. Speck, and H. W. Virgin IV Murine Gammaherpesvirus 68 Encodes a Functional Regulator of Complement Activation J. Virol., September 1, 1999; 73(9): 7658 - 7670. [Abstract] [Full Text]
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L. Liu, E. Flano, E. J. Usherwood, S. Surman, M. A. Blackman, and D. L. Woodland Lytic Cycle T Cell Epitopes Are Expressed in Two Distinct Phases During MHV-68 Infection J. Immunol., July 15, 1999; 163(2): 868 - 874. [Abstract] [Full Text] [PDF]
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S. M. Husain, E. J. Usherwood, H. Dyson, C. Coleclough, M. A. Coppola, D. L. Woodland, M. A. Blackman, J. P. Stewart, and J. T. Sample Murine gammaherpesvirus M2 gene is latency-associated and its protein a target for CD8+ T lymphocytes PNAS, June 22, 1999; 96(13): 7508 - 7513. [Abstract] [Full Text] [PDF]
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K. E. Weck, S. S. Kim, H. W. Virgin IV, and S. H. Speck B Cells Regulate Murine Gammaherpesvirus 68 Latency J. Virol., June 1, 1999; 73(6): 4651 - 4661. [Abstract] [Full Text]
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V. van Berkel, K. Preiter, H. W. Virgin IV, and S. H. Speck Identification and Initial Characterization of the Murine Gammaherpesvirus 68 Gene M3, Encoding an Abundantly Secreted Protein J. Virol., May 1, 1999; 73(5): 4524 - 4529. [Abstract] [Full Text]
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J. P. Christensen, R. D. Cardin, K. C. Branum, and P. C. Doherty CD4+ T cell-mediated control of a gamma -herpesvirus in B cell-deficient mice is mediated by IFN-gamma PNAS, April 27, 1999; 96(9): 5135 - 5140. [Abstract] [Full Text] [PDF]
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K. E. Weck, S. S. Kim, H. W. Virgin IV, and S. H. Speck Macrophages Are the Major Reservoir of Latent Murine Gammaherpesvirus 68 in Peritoneal Cells J. Virol., April 1, 1999; 73(4): 3273 - 3283. [Abstract] [Full Text]
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H. W. Virgin IV, R. M. Presti, X.-Y. Li, C. Liu, and S. H. Speck Three Distinct Regions of the Murine Gammaherpesvirus 68 Genome Are Transcriptionally Active in Latently Infected Mice J. Virol., March 1, 1999; 73(3): 2321 - 2332. [Abstract] [Full Text]
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J. Simas, D Swann, R Bowden, and S Efstathiou Analysis of murine gammaherpesvirus-68 transcription during lytic and latent infection J. Gen. Virol., January 1, 1999; 80(1): 75 - 82. [Abstract]
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P. G. Stevenson and P. C. Doherty Kinetic Analysis of the Specific Host Response to a Murine Gammaherpesvirus J. Virol., February 1, 1998; 72(2): 943 - 949. [Abstract] [Full Text] [PDF]
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J. Simas, R. Bowden, V Paige, and S Efstathiou Four tRNA-like sequences and a serpin homologue encoded by murine gammaherpesvirus 68 are dispensable for lytic replication in vitro and latency in vivo J. Gen. Virol., January 1, 1998; 79(1): 149 - 153. [Abstract]
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 R. A. Tripp, A. M. Hamilton-Easton, R. D. Cardin, P. Nguyen, F. G. Behm, D. L. Woodland, P. C. Doherty, and M. A. Blackman Pathogenesis of an Infectious Mononucleosis-like Disease Induced by a Murine gamma -Herpesvirus: Role for a Viral Superantigen? J. Exp. Med., May 5, 1997; 185(9): 1641 - 1650. [Abstract] [Full Text] [PDF]
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S. R. Sarawar, B. J. Lee, S. K. Reiter, and S. P. Schoenberger Stimulation via CD40 can substitute for CD4 T cell function in preventing reactivation of a latent herpesvirus PNAS, May 22, 2001; 98(11): 6325 - 6329. [Abstract] [Full Text] [PDF]
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P. G. Stevenson, S. Efstathiou, P. C. Doherty, and P. J. Lehner Inhibition of MHC class I-restricted antigen presentation by gamma 2-herpesviruses PNAS, July 18, 2000; 97(15): 8455 - 8460. [Abstract] [Full Text] [PDF]
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