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Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, U.K.
Short nucleotide sequence analysis of seven restriction fragments of murine herpesvirus 68 (MHV-68) DNA has been undertaken and used to determine the overall genome organization and relatedness of this virus to other well characterized representatives of the alpha-, beta- and gammaherpesvirus subgroups. Nine genes have been identified which encode amino acid sequences with greater similarity to proteins of the gammaherpesvirus Epstein-Barr virus (EBV) than to the homologous products of the alphaherpesviruses varicella-zoster virus and herpes simples virus type 1 or the betaherpesvirus human cytomegalovirus. In addition, the genome organization of MHV-68 is shown to have an overall collinearity with that of the gamma-herpesviruses EBV and herpesvirus saimiri. In common with these viruses, dinucleotide frequency analysis of MHV-68 coding sequences reveals a marked reduction in CpG dinucleotide frequency thus implicating a dividing cell population as the site of latency in vivo.
Received 5 December 1989;
accepted 22 February 1990.
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P. G. Stevenson and P. C. Doherty Non-Antigen-Specific B-Cell Activation following Murine Gammaherpesvirus Infection Is CD4 Independent In Vitro but CD4 Dependent In Vivo J. Virol., February 1, 1999; 73(2): 1075 - 1079. [Abstract] [Full Text]
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J. Simas, D Swann, R Bowden, and S Efstathiou Analysis of murine gammaherpesvirus-68 transcription during lytic and latent infection J. Gen. Virol., January 1, 1999; 80(1): 75 - 82. [Abstract]
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J. Simas, R. Bowden, V Paige, and S Efstathiou Four tRNA-like sequences and a serpin homologue encoded by murine gammaherpesvirus 68 are dispensable for lytic replication in vitro and latency in vivo J. Gen. Virol., January 1, 1998; 79(1): 149 - 153. [Abstract]
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R. A. Tripp, A. M. Hamilton-Easton, R. D. Cardin, P. Nguyen, F. G. Behm, D. L. Woodland, P. C. Doherty, and M. A. Blackman Pathogenesis of an Infectious Mononucleosis-like Disease Induced by a Murine gamma -Herpesvirus: Role for a Viral Superantigen? J. Exp. Med., May 5, 1997; 185(9): 1641 - 1650. [Abstract] [Full Text] [PDF]
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G. T. Belz, P. G. Stevenson, M. R. Castrucci, J. D. Altman, and P. C. Doherty Postexposure vaccination massively increases the prevalence of gamma -herpesvirus-specific CD8+ T cells but confers minimal survival advantage on CD4-deficient mice PNAS, March 14, 2000; 97(6): 2725 - 2730. [Abstract] [Full Text] [PDF]
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