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Department of Medicine, St Mary's Hospital Medical School, London W2 1NY, U.K.
The RNA of hepatitis delta virus (HDV) 1682 nucleotides long, has been cloned from a human serum isolate. Comparison with the three complete published sequences shows that a region of the HDV genome, between positions 620 and 1350, which contains sequences involved in replication and possibly pathogenicity, is highly conserved.
Received 18 December 1989;
accepted 6 March 1990.
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