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The Nucleotide Sequence of the Equine Herpesvirus 4 Thymidine Kinase Gene

¹ Department of Veterinary Pathology, University of Glasgow Veterinary School, Bearsden Road, Bearsden, Glasgow G61 1QH, U.K.
and² Irish Equine Centre, Johnstown, Naas, County Kildare, Eire

We have determined the genomic location and nucleotide sequence of the equine herpesvirus 4 thymidine kinase (TK) gene. The gene is positioned at approximately 0.48 map units within the long unique component of the genome and is flanked by genes encoding a herpes simplex virus 1 (HSV-1) UL24 homologue and glycoprotein H. The predicted protein is composed of 352 amino acids, has an M_r of 38800 and exhibits 36% identity to the predicted TK of HSV-1.

Received 29 March 1990; accepted 24 April 1990.