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Human Papillomavirus Type 16 DNA Expresses a Replication Modulation Factor in cos-1 Cells

Eva-Maria Hecht

P. M. Chesters^>

D. J. McCance

Department of Microbiology, U.M.D.S. Guy's Campus, London Bridge SE1 9RT, U.K.

Plasmid DNA including the simian virus 40 (SV40) origin of replication undergoes uncontrolled, runaway replication in cos-1 cells owing to the intracellular production of SV40 large T antigen. Covalent linkage of such plasmids with human papillomavirus type 16 (HPV-16) DNA was found to prevent runaway replication. Replication control was found to be dependent on the presence of HPV-16 DNA sequences including the E1 open reading frame and part of the non-coding region.

Present address: Department of Immunology, U.M.D.S. Guy's Campus, London SE1 9RT, U.K.

^> Present address: Department of Medical Microbiology, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, U.K.

Present address: Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, U.S.A.

Received 7 November 1989; accepted 9 April 1990.