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J Gen Virol 71 (1990), 1975-1983; DOI 10.1099/0022-1317-71-9-1975
© 1990 Society for General Microbiology
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The immunodominance of epitopes within the transmembrane protein (gp41) of human immunodeficiency virus type 1 may be determined by the host's previous exposure to similar epitopes on unrelated antigens

David Davis1, Babar Chaudhri1, D. Michael Stephens1, Christopher A. Carne2, Christine Willers1 and Peter J. Lachmann1

1 Molecular Immunopathology Unit, MRC Centre, Hills Road, Cambridge CB2 2QH
and2 Department of Genito-Urinary Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, U.K.

Six major epitopes have been recognized within the transmembrane gp41 molecule of human immunodeficiency virus type 1 (HIV-1). The immunodominant epitope is also recognized by antibodies in sera from laboratory personnel and is similar to a linear sequence of amino acids in the genome protein of two rhinovirus serotypes. The hypothesis is presented that immunodominance is produced by multiple priming of the host, following repeated infections with viruses unrelated to HIV-1, which share similar epitopes.

Received 6 March 1990; accepted 24 May 1990.


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