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Isolation and purification of a non-A, non-B hepatitis-associated microtubular aggregates protein

Yoshikazu Honda^1,

Toshiro Maeda^2,

Ei Yamada^1,

¹ Departments of Microbiology
and² Departments Pathology, Nihon University, School of Medicine, Itabashi-ku, Tokyo 173
³ Biosciences Laboratory, Life Science Research Sector, Research Center, Mitsubishi Kasei Corporation, 1000 Kamoshida-cho, Midori-ku, Yokohama 227
and⁴ Department of Enteroviruses, National Institute of Health, Musashimurayama, Tokyo 190-12, Japan

Blood-borne type non-A, non-B (NANB) hepatitis-associated microtubular aggregates protein was isolated and partially sequenced. The microtubular aggregates were isolated from the hepatocytes of NANB-infected chimpanzees and were found to have a buoyant density in sucrose solution of 1.21 to 1.23 g/ml. A single protein, recognized by our anti-microtubular aggregates monoclonal antibodies, was found to have an M_r of 44000 (p44). This p44 protein was not found in uninfected chimpanzees. We determined a partial amino acid sequence for p44, and showed that it has no homology to any known proteins.

Present address: Biosciences Laboratory, Life Science Research Sector, Research Center, Mitsubishi Kasei Corporation, 1000 Kamoshida-cho, Midori-ku, Yokohama 227, Japan.

Received 1 February 1990; accepted 9 May 1990.

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