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Immunological relationships of simian virus 41 (SV41) to other paramyxoviruses and serological evidence of SV41 infection in human populations

Department of Microbiology, Mie University School of Medicine, 2-174 Edobashi, Tsu-Shi, Mie-Prefecture 514, Japan

Antigenic relationships of simian virus 41 (SV41) to other paramyxoviruses were examined by immunoprecipitation of isotope-labelled SV41-infected cell lysates with specific antisera. SV41 is closely related to the group comprising human parainfluenza virus 2 (HPIV-2), simian virus 5 (SV5), parainfluenza virus 4 and mumps virus. Slight cross-neutralization was detected between SV41, HPIV-2 and SV5. Anti-SV41 activities were detected in 21 of 1116 human serum specimens, indicating that a proportion of the human population is infected with SV41. The haemagglutinin—neuraminidase of SV41 was preferentially immunoprecipitated by anti-SV41 positive sera.

Received 5 March 1990; accepted 30 April 1990.