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J Gen Virol 71 (1990), 2175-2178; DOI 10.1099/0022-1317-71-9-2175
© 1990 Society for General Microbiology
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Induction of cervical neoplasia in the mouse by an extract of cells infected by varicella-zoster virus

Alfred D. Heggie1,3,, W. Budd Wentz2, Kelly Sorensen3 and Donald D. Anthony4

1 Department of Pediatrics
2 Department of Reproductive Biology
3 Department of Pathology
and4 Department of Pharmacology, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, 2074 Abington Road, Cleveland, Ohio 44106, U.S.A.

Since several human herpesviruses, including varicella-zoster virus (VZV), have been demonstrated to transform mammalian cells in vitro, VZV was tested in a mouse model of virus-induced cervical neoplasia to determine whether it is oncogenic in vivo. Herpes simplex viruses types 1 and 2 and cytomegalovirus have been previously shown to induce cervical neoplasia in this mouse model. VZV was propagated in WI-38 cell cultures and inactivated by ultraviolet irradiation. Control material was prepared in an identical manner from uninfected cell cultures. Cotton tampons, saturated with inactivated virus or control material, were inserted into the vaginas of C57BL mice three times a week for 60 weeks. Cervical dysplasia was detected in 40% and invasive carcinoma in 34% of virus-exposed mice by histological examination. No lesions were detected in control animals. These observations indicate that VZV, or some product of virus-infected cells, is oncogenic in vivo for the mouse cervix.

Received 24 January 1990; accepted 24 May 1990.




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