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Physicochemical Characterization of Human Herpesvirus 6 Infectivity

Kimiyasu Shiraki

Department of Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565, Japan

Infectivity of human herpesvirus 6 (HHV-6) was physicochemically characterized. Virus particles were excreted from infected cord blood mononuclear cells into the culture supernatant at a concentration of 10⁸ to 10⁹ virus particles/ml. The virus particle/infectivity ratio of HHV-6 in the culture supernatant was approximately 10³:1 and that in the sonicated infected cells was 10⁴:1. Infectivity was stable below 37 °C and at neutral pH (7.0 to 8.5). These fundamental data may be useful for serological and biological research on HHV-6.

Present address: Department of Virology, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930-01, Japan.

Received 10 July 1990; accepted 4 October 1990.

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