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In vivo detection of metabolic changes in a mouse model of scrapie using nuclear magnetic resonance spectroscopy

¹ NMR Unit, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, London W12 0HS
² Department of Chemistry, Queen Mary and Westfield College, Mile End Road, London E1 4NS
³ AFRC Institute of Food Research, Norwich Laboratory, Norwich Science Park, Colney, Norwich NR4 7UA
and⁴ AFRC Institute for Animal Health, ARFC & MRC Neuropathogenesis Unit, Ogston Building, West Mains Road, Edinburgh EH9 3JF, U.K.

In vivo proton nuclear magnetic resonance (NMR) spectroscopy studies of scrapie in a mouse model have shown the appearance of an abnormal peak in the brain early in the incubation period. This abnormal peak was detected weeks before the detection of a protease-resistant form of a membrane protein and vacuolar histopathology in vitro, and several months before clinical signs, and the signal increased in intensity as the disease progressed. In the chronic stage of the disease, a reduction in N-acetyl aspartate levels was observed using in vivo and in vitro proton NMR spectroscopy.

Received 8 May 1991; accepted 17 June 1991.