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J Gen Virol 72 (1991), 2569-2572; DOI 10.1099/0022-1317-72-10-2569
© 1991 Society for General Microbiology
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Presence and integration of human papillomavirus type 6 in a tonsillar carcinoma

Jorge Andres Bercovich1, Carlos Ries Centeno2, Osvaldo González Aguilar2, Saúl Grinstein1 and Tomas Kahn3

1 Virology Laboratory, Buenos Aires Children's Hospital, Gallo 1330, 1425 Buenos Aires
2 Head and Neck Surgery Department, Oncology Hospital of Buenos Aires, Buenos Aires, Argentina
and3 Deutsches Krebsforschungszentrum, Institut für Virusforschung, Im Neuenheimer Feld 506, 6900 Heidelberg, Germany

Human papillomavirus type 6 subtype a (HPV-6a0 was detected in a human invasive tonsillar carcinoma. Southern blot hybridization analysis showed the presence of additional bands when using non-cutting and single-cut restriction enzymes. Molecular cloning yielded two recombinant clones of 8.0 and 1.4 kb in size. The first represents the complete HPV-6a genome. Sequence analysis of the second clone showed a 0.6 kb DNA sequence corresponding to the L2 region of HPV-6a, whereas the rest belongs to cellular sequences. These data show the presence of a usually low risk HPV type in an invasive carcinoma, at an unusual infection site, with viral DNA integrated into the host genome. These findings add evidence in support of the hypothesis of a relationship between HPV infection and at least some ororespiratory cancers.

Received 5 April 1991; accepted 8 July 1991.


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HPV infections and tonsillar carcinoma
J. Clin. Pathol., May 1, 2004; 57(5): 449 - 455.
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