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Sequencing data on the long control region of human papillomavirus type 16

Maja Krajinovi^1,2

Ana Savi²

¹ Institute of Biology and Human Genetics, Medical School, University of Belgrade
and² Institute of Molecular Genetics and Genetic Engineering, P.O. Box 794, 11001 Belgrade, Yugoslavia

A one base change (adenine at position 7861) in the long control region (LCR) of the prototype sequence of human papillomavirus type 16 was reported. With this correction, a new E2-binding site was revealed, 111 bp and 143 bp upstream from the TATA box and P97, respectively, and 105 bp downstream of the keratinocyte-dependent enhancer. An A to C mutation at position 41 was found in a patient with invasive carcinoma. This mutation falls within an E2-binding site.

Received 24 January 1991; accepted 11 June 1991.