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Activation of latent papillomavirus genomes by chronic mechanical irritation

¹ Institute for Experimental Pathology
and² Institute for Virus Research, German Cancer Research Center, Neuenheimer Feld 280, 6900 Heidelberg, Germany

The skin of animals of a laboratory strain of Mastomys natalensis carrying endogenous, latent papillomavirus genomes was irritated by scratching with glasspaper. Hyperproliferation of the epidermis and amplification of viral DNA followed this treatment, and in approximately 27% of the animals virus-producing papillomas were induced.

Received 28 February 1991; accepted 8 July 1991.

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