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cDNA clones of Japanese hepatitis C virus genomes derived from a single patient show sequence heterogeneity

¹ Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co. Ltd, 1-135 Komakado, Gotemba-shi, Shizuoka 412
and The² Second Department of Internal Medicine, Faculty of Medicine, Kagoshima University, 1208-1 Usuki-cho, Kagoshima 890, Japan

Twelve cDNA clones of Japanese hepatitis C virus (HCV) have been isolated from liver tissue of a single non-A, non-B hepatitis patient. These clones represented the non-structural domains of HCV. The degree of substitution in the nucleotide sequences and deduced amino acid sequences between these clones was 9·5 and 7·7%, respectively. This high level of substitution suggested that repeated infections of different HCVs may have occurred in the patient.

Received 3 April 1991; accepted 31 July 1991.

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