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Sequence Comparison Between the Haemagglutinin-neuraminidase Genes of Simian, Canine and Human Isolates of Simian Virus 5

Department of Biochemistry and Microbiology, University of St Andrews, St Andrews, Fife KY16 9AL, U.K.

The nucleotide sequence of the haemagglutinin-neuraminidase (HN) gene was determined for a simian (W3), human (LN) and two canine (CPI+/CPI-) isolates of simian virus 5 (SV5). A comparison of the predicted amino acid sequences revealed that the human and canine isolates varied from the simian isolate by 1.7% and 2.4% respectively. This lack of significant variation between the HN proteins of the four SV5 isolates suggests that insufficient differences have occurred between isolates to confine them to a specific host.

Received 10 June 1991; accepted 20 August 1991.

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