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1 Institute of Biochemistry, University of Vienna, Währingerstrasse 17, A-1090 Vienna, Austria
2 Department of Virology and Oncopharmacology
and3 Department of Medical Chemistry, Sterling Research Group, 81 Columbia Turnpike, Rensselaer, New York 12144, U.S.A.
Four WIN compounds with anti-picornavirus activities were tested for their ability to stabilize human rhinovirus serotype 2 (HRV-2) against low pH-induced conformational changes in vitro, as determined by specific immunoprecipitation. These results were compared to the minimal inhibitory concentration (MIC) as measured in a plaque reduction assay. A direct relationship was observed between the concentration of the compound that prevented the low pH-induced conformational changes and the MIC, indicating that stabilization is an important element in the mode of action of these drugs against HRV-2.
Received 21 August 1990;
accepted 22 October 1990.
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