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Sequence conservation of the outer capsid protein, VP5, of bluetongue virus, a contrasting feature to the outer capsid protein VP2

¹ NERC Institute of Virology and Environmental Microbiology, Mansfield Road, Oxford OX1 3SR, U.K.
and² Department of Environmental Health Sciences, School of Public Health, University of Alabama, Birmingham, Alabama 35294, U.S.A.

The complete nucleotide sequence of a cDNA clone representing the segment 5 RNA of bluetongue virus (BTV) United States serotype 13 was determined. The comparison of the predicted amino acid sequence of the encoded protein (VP5) with the sequences of VP5 from two BTV United States serotypes, 10 and 2, and two isolates of BTV serotype 1 (Australian and South African), revealed that the protein is highly conserved among the different serotypes despite their geographical separation.

Received 22 August 1990; accepted 30 October 1990.