HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Jakeman, K. J. Articles by Sweet, C. Search for Related Content PubMed PubMed Citation Articles by Jakeman, K. J. Articles by Sweet, C. Agricola Articles by Jakeman, K. J. Articles by Sweet, C.

Nature of the endogenous pyrogen (EP) induced by influenza viruses: lack of correlation between EP levels and content of the known pyrogenic cytokines, interleukin 1, interleukin 6 and tumour necrosis factor

The¹ Microbial Molecular Genetics and Cell Biology Research Group, School of Biological Sciences
and² The Medical School, University of Birmingham B15 2TT
and³ Division of Immunology, National Institute for Biological Standards and Control, South Mimms, Potters Bar, Hertfordshire EN6 3QG, U.K.

Fever in influenza results from the release of endogenous pyrogen (EP) following virus-phagocyte interaction and its level correlates with the differing virulence of virus strains. However, the different levels of fever produced in ferrets by intracardial inoculation of EP obtained from the interaction of different virus strains with ferret or human phagocytes did not correlate with the levels of interleukin 1 (IL-1), IL-6 or tumour necrosis factor in the same samples as assayed by conventional in vitro methods. Hence, the EP produced by influenza virus appears to be different to these cytokines.

Received 1 October 1990; accepted 3 December 1990.

This article has been cited by other articles:

				S. H. Seo and R. G. Webster Tumor Necrosis Factor Alpha Exerts Powerful Anti-Influenza Virus Effects in Lung Epithelial Cells J. Virol., February 1, 2002; 76(3): 1071 - 1076. [Abstract] [Full Text] [PDF]