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J Gen Virol 72 (1991), 1105-1111; DOI 10.1099/0022-1317-72-5-1105
© 1991 Society for General Microbiology
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The inhibitory effects of oligonucleotides, complementary to Marek's disease virus mRNA transcribed from the BamHI-H region, on the proliferation of transformed lymphoblastoid cells, MDCC-MSB1

Mikiko Kawamura1, Masanobu Hayashi1, Tatsuya Furuichi1, Meihan Nonoyama2, Emiko Isogai3 and Shigeo Namioka1

1 Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060, Japan
2 Department of Virology, Tampa Bay Research Institute, 10900 Roosevelt Boulevard North, St Petersburg, Florida 33716, U.S.A.
and3 Department of Preventive Dentistry, School of Dentistry, Higashi Nippon Gakuen University, Tobetsu 069, Japan

An oligonucleotide complementary to the splice donor sequence of the 1.8 kb gene family produced from the BamHI-H region of Marek's disease virus (MDV) DNA inhibited the proliferation of the MDV-derived lymphoblastoid cell line, MDCC-MSB1 (MSB-1), but not that of the avian lymphoid leukosis-derived lymphoblastoid cell line, LSCC-BK3. Colony formation in soft agar was also inhibited by treatment of MSB-1 cells with the antisense oligonucleotide. It is hypothesized that expression of the 1.8 kb gene family produced from the BamHI-H region is directly associated with the maintenance of the tumorigenic state of transformed Marek's disease-derived lymphoblastoid cells.

Received 13 September 1990; accepted 25 January 1991.


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