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J Gen Virol 72 (1991), 1195-1198; DOI 10.1099/0022-1317-72-5-1195
© 1991 Society for General Microbiology
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Characterization of monoclonal antibodies to bovine viral diarrhoea virus: evidence of a neutralizing activity against gp48 in the presence of goat anti-mouse immunoglobulin serum

D. Boulanger, S. Waxweiler, L. Karelle, M. Loncar, B. Mignon, J. Dubuisson, E. Thiry and P.-P. Pastoret

Department of Virology-Immunology, Faculty of Veterinary Medicine, University of Liège, Institut de Chimie - B6 (R80), 4000 Liège, Belgium

Twenty-one monoclonal antibodies (MAbs) directed against the NY-1 and the Osloss-c strains of bovine viral diarrhoea virus were produced and characterized by indirect immunofluorescence assay, radioimmuno-precipitation and neutralization tests. Fourteen MAbs directed against the NY-1 strain recognized the gp48 and showed a weak neutralizing activity in the presence of goat anti-mouse immunoglobulin serum.

Received 22 May 1990; accepted 18 January 1991.


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