HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by McLorie, W. Articles by Branton, P. E. Search for Related Content PubMed PubMed Citation Articles by McLorie, W. Articles by Branton, P. E. Agricola Articles by McLorie, W. Articles by Branton, P. E.

Individual adenovirus E1B proteins induce transformation independently but by additive pathways

Philip E. Branton^2,3,

¹ Department of Biology, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
and² Department of Pathology
³ Department of Pathology, McMaster University, Hamilton, Ontario, Canada L8N 3Z5

The specific contributions of human adenovirus type 5 early region 1B (E1B) proteins were examined using mutants which synthesize these products individually. In cooperation with E1A, transformation of primary baby rat kidney cells was achieved with either the 176R protein or 496R protein alone, albeit at an efficiency considerably less than that observed when both were present. These results indicate that transformation mediated by either E1B product can proceed independently, but that the processes involved are additive.

Present address: Department of Biochemistry, McGill University, 3655 Drummond Street, Montreal, Quebec, Canada H3G 1Y6.

Received 25 June 1990; accepted 4 February 1991.

This article has been cited by other articles:

				D. Boivin, M. R. Morrison, R. C. Marcellus, E. Querido, and P. E. Branton Analysis of Synthesis, Stability, Phosphorylation, and Interacting Polypeptides of the 34-Kilodalton Product of Open Reading Frame 6 of the Early Region 4 Protein of Human Adenovirus Type 5 J. Virol., February 1, 1999; 73(2): 1245 - 1253. [Abstract] [Full Text]

				F. W.H. Ng, M. Nguyen, T. Kwan, P. E. Branton, D. W. Nicholson, J. A. Cromlish, and G. C. Shore p28 Bap31, a Bcl-2/Bcl-XL- and Procaspase-8-associated Protein in the Endoplasmic Reticulum J. Cell Biol., October 20, 1997; 139(2): 327 - 338. [Abstract] [Full Text] [PDF]