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J Gen Virol 72 (1991), 1467-1471; DOI 10.1099/0022-1317-72-6-1467
© 1991 Society for General Microbiology
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Individual adenovirus E1B proteins induce transformation independently but by additive pathways

Whynn McLorie1,3,, C. Jane McGlade3, Dennis Takayesu3 and Philip E. Branton2,3,{dagger}

1 Department of Biology, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
and2 Department of Pathology
3 Department of Pathology, McMaster University, Hamilton, Ontario, Canada L8N 3Z5

The specific contributions of human adenovirus type 5 early region 1B (E1B) proteins were examined using mutants which synthesize these products individually. In cooperation with E1A, transformation of primary baby rat kidney cells was achieved with either the 176R protein or 496R protein alone, albeit at an efficiency considerably less than that observed when both were present. These results indicate that transformation mediated by either E1B product can proceed independently, but that the processes involved are additive.

{dagger} Present address: Department of Biochemistry, McGill University, 3655 Drummond Street, Montreal, Quebec, Canada H3G 1Y6.

Received 25 June 1990; accepted 4 February 1991.


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