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Localization of antigenic sites on the surface glycoprotein of mouse hepatitis virus

Institute of Virology and Immunobiology, University of Würzburg, Versbacher Strasse 7, D-8700 Würzburg, Germany

A panel of murine hepatitis virus (MHV) surface (S) glycoprotein-specific monoclonal antibodies (MAbs), which recognize either continuous or discontinuous epitopes, were tested in competitive binding assays. The results indicate that the binding site of MAb 30B amino acids 395 to 406 in the amino-terminal S₁ subunit, is involved in the discontinuous epitope designated antigenic site A. This site is a major determinant for the induction of neutralizing antibodies. These data define, for the first time, the location of a functionally important domain on the MHV S protein.

Received 14 February 1991; accepted 3 April 1991.