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Binding of the BL/VL3 murine T cell lymphoma to radiation leukaemia virus is specific for viral env determinants

Developmental Haematology Group, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia

Molecularly cloned radiation leukaemia viruses (RadLVs) isolated from the BL/VL3 radiation-induced thymoma have been used in assays to compare the binding specificity of the BL/VL3 cell line for different retroviruses. BL/VL3 cells bound well to two of three thymotropic, leukaemogenic viruses produced by this cell line. BL/VL3 did not bind to a cloned fibrotropic, non-leukaemogenic RadLV. BL/VL3 appears to have receptor specificity for only some of the leukaemogenic RadLVs, and this appears to be related to differences in the viral env sequence.

Received 21 December 1990; accepted 11 April 1991.