| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Veterinary Hygiene and Microbiology, School of Veterinary Medicine, Hokkaido University, Sapporo 060, Japan
and2 Department of Microbiology, University of Hong Kong, Pathology Building, Queen Mary Hospital Compound, Hong Kong
The haemagglutinins (HAs) of five H3 influenza A viruses isolated from domestic ducks and one from a goose in southern China were analysed antigenically and genetically. The patterns of reactivity of two of the duck viruses and the goose virus with a panel of monoclonal antibodies to 10 different epitopes on the H3 HA were similar to those of influenza viruses isolated from wild ducks and pigs, as well as those of the earliest human H3 viruses. The other three isolates from domestic ducks were different from each other and from these viruses antigenically. Sequence analysis revealed that the HA genes of the two duck viruses and the goose virus were closely related to those of isolates from wild ducks and pigs; the identities between the deduced amino acid sequence of the HA of one of the isolates from domestic ducks and those of isolates from a wild duck and a pig were 98·7% and 99·5%, respectively. The antigenic and genetic similarity between these H3 HAs suggests that in southern China, the hypothetical influenza epicentre, domestic ducks may have played a role in the introduction of avian influenza viruses to pigs from feral ducks. The findings also support the hypothesis that the pig was a ‘mixing vessel’, producing a new human pandemic strain, A/Hong Kong/68 (H3N2), by genetic reassortment.
Received 4 February 1991;
accepted 7 May 1991.
This article has been cited by other articles:
|
|
 |
|
  R. G. Webster, S. Krauss, D. Hulse-Post, and K. Sturm-Ramirez EVOLUTION OF INFLUENZA A VIRUSES IN WILD BIRDS J. Wildl. Dis., July 1, 2007; 43(3_Supplement): S1 - S6. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. M. Fouchier, P. M. Schneeberger, F. W. Rozendaal, J. M. Broekman, S. A. G. Kemink, V. Munster, T. Kuiken, G. F. Rimmelzwaan, M. Schutten, G. J. J. van Doornum, et al. Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome PNAS, February 3, 2004; 101(5): 1356 - 1361. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Takada, N. Kuboki, K. Okazaki, A. Ninomiya, H. Tanaka, H. Ozaki, S. Itamura, H. Nishimura, M. Enami, M. Tashiro, et al. Avirulent Avian Influenza Virus as a Vaccine Strain against a Potential Human Pandemic J. Virol., October 1, 1999; 73(10): 8303 - 8307. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
