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Nucleotide sequence analysis of a unique near-terminal region of the tumorigenic poxvirus, Shope fibroma virus

R. F. Massung^1,

¹ Department of Immunology and Medical Microbiology, PO Box 100266, College of Medicine, University of Florida, Gainesville, Florida 32610, U.S.A.
and² Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada TG6 2H7

Shope fibroma virus (SFV), a tumorigenic poxvirus, has a DNA genome of approximately 160 kb. Previous DNA sequence analysis of SFV has been mainly limited to the terminal inverted repetitions (about 12 kb at each end of the genome) and immediately adjacent regions. We have sequenced a 4 kb fragment located approximately 20 kb from the right-terminal hairpin. Within this region three complete and two partial open reading frames (ORFs) have been identified. Each of the putative polypeptides has sequence similarity to one or more previously identified poxvirus or cellular proteins, with homology to protein kinases, erythrocyte ankyrin and a vaccinia virus virulence-related protein (ORF N1L). The potential significance of these gene products with regard to the phenotype of SFV is discussed.

Present address: Centers for Disease Control, Atlanta, Georgia, U.S.A.

Received 22 April 1992; accepted 22 July 1992.

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