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Open reading frames 1 and 2 of adenovirus region E4 are conserved between human serotypes 2 and 5

Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, U.K.

The E4 region of human adenovirus type 2 is predicted to encode seven proteins as judged from its nucleotide sequence and the pattern of differential splicing of its transcript. Two of the open reading frames (ORFs), ORF1 and ORF2, had been identified as being disrupted in the recently published sequence of the related serotype 5 virus. These ORFs were resequenced and found to be intact in the wt300 strain of adenovirus type 5.

Received 24 June 1992; accepted 21 July 1992.

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