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1 Institute for Virus Research, Kyoto University, Kyoto 606
2 Tsukuba Primate Center for Medical Science, National Institute of Health, Tsukuba 305
3 Division of Poxviruses and Special Pathogens, National Institute of Health, Musashimurayama 190-12
and4 Institute of Tropical Medicine, Nagasaki University, Nagasaki 852, Japan
Two macaque monkeys were inoculated with a chimeric human and simian immunodeficiency virus carrying the tat, rev, vpu and env genes of human immunodeficiency virus type 1. Infectious virus was recovered from one of the monkeys at 2 and 6 weeks post-infection. The hybrid nature of the isolated viruses was verified by Southern and Western blotting analyses. Both of the monkeys infected with the chimera elicited a humoral antibody response against the virus.
Received 24 April 1992;
accepted 27 July 1992.
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