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Sequences responsible for efficient replication of simian immunodeficiency virus SIV_MND in cells of the monocyte/macrophage lineage

Institute for Virus Research, Kyoto University, Kyoto 606, Japan

We determined the susceptibility of monocytic cell lines to infection with viral strains derived from two infectious clones of simian immunodeficiency virus isolated from a mandrill. One of the strains, which replicates poorly in T cell lines, was found to grow more rapidly than the other in these cells. The viral determinant for this property was genetically mapped within the env gene encoding a surface protein. Six amino acid substitutions identified appeared to be located outside of the domains corresponding to human immunodeficiency virus type 1 env functional domains such as the CD4-binding and V3 loop regions.

Received 7 April 1992; accepted 22 July 1992.