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J Gen Virol 73 (1992), 3005-3009; DOI 10.1099/0022-1317-73-11-3005
© 1992 Society for General Microbiology
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Genomic variability in the preS1 region and determination of routes of transmission of hepatitis B virus

Angela Uy1, Gerhard Wunderlich1, David B. Olsen2,{dagger}, Klaus-Hinrich Heermann1, Wolfram H. Gerlich1,{ddagger}> and Reiner Thomssen1

1 Department of Medical Microbiology, Georg August University, Göttingen
and2 Max Planck Institute of Experimental Medicine, Department of Chemistry, Göttingen, Germany

On the basis of published sequence data the preS1 attachment region of hepatitis B virus (HBV) appears to be highly variable. Using a novel method for rapid DNA sequencing by the polymerase chain reaction we screened 34 HBV DNA-positive sera for mutations in a variable part of the preS1 region of the HBV genome. The sequence data were used to analyse potential chains of infection, and strongly supported the expected routes of HBV transmission among patient groups. Furthermore, sequence comparisons permitted sub-genotyping of the viruses. In the 22 cases of subtype adw, we found a very low number of point mutations. This shows that the attachment site of HBV is more highly conserved than that of other blood-transmissible viruses such as human immunodeficiency virus or hepatitis C virus.

{dagger} Present address: Merck, Sharp and Dohme Research Laboratories, West Point, Pennsylvania 19486, U.S.A.

{ddagger}> Present address: Department of Medical Virology, Justus Liebig University, Giessen, Germany.

Received 17 March 1992; accepted 10 July 1992.


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Copyright © 1992 by the Society for General Microbiology.