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J Gen Virol 73 (1992), 3285-3288; DOI 10.1099/0022-1317-73-12-3285
© 1992 Society for General Microbiology
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Differential in vitro inhibition of feline enteric coronavirus and feline infectious peritonitis virus by actinomycin D

Evelyn L. Lewis1, D. A. Harbour1, J. E. Beringer2 and J. Grinsted3

1 Department of Veterinary Medicine, Langford House, Bristol BS18 7DU
2 Department of Botany and Zoology, Woodland Road, Bristol BS8 1UG
and3 Department of Pathology and Microbiology, Medical School, University of Bristol, University Walk, Bristol BS8 1TD, U.K.

The growth of feline enteric coronavirus strain 79-1683 in whole feline embryo cells was inhibited by the presence of 1 µg/ml of actinomycin D in the culture fluid. No virus-specific mRNAs could be detected in such cultures and yields of infectious virus were depressed by >99%. By contrast, the antigenically related feline infectious peritonitis virus strain 79-1146 was unaffected by the presence of actinomycin D, indicating a fundamental difference between the two feline coronavirus strains in their requirements for host-encoded function(s).

Received 21 April 1992; accepted 1 September 1992.


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Copyright © 1992 by the Society for General Microbiology.