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J Gen Virol 73 (1992), 507-512; DOI 10.1099/0022-1317-73-3-507
© 1992 Society for General Microbiology
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beta2 Microglobulin on the envelope of urinary cytomegalovirus is not associated with host class I human leukocyte antigen {alpha} chain

Jane S. L. Rose{dagger} and Jane E. Grundy

Department of Virology, Royal Free Hospital School of Medicine, London NW3 2PF, U.K.

Previous studies have shown that beta2 microglobulin (beta2m) is associated with glycoproteins present on the envelope of urinary human cytomegalovirus (CMV). beta2m is non-covalently associated with the {alpha} chain of human leukocyte antigen (HLA) class I antigens and therefore it was of interest to determine whether the class I {alpha} chain is also associated with the beta2m–CMV complex. Using a panel of monoclonal antibodies recognizing different conformational determinants on the HLA class I heterodimer or free beta2m, we have shown that beta2m but not the {alpha} chain of HLA class I could be immunoprecipitated from 125I-surface-labelled virions purified directly from urine. We therefore conclude that host class I HLA {alpha} chains are not associated with beta2m on the envelope of urinary CMV.

{dagger} Present address: National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar EN6 3QG, U.K.

Received 20 March 1991; accepted 15 November 1991.


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