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1 Japanese Red Cross Blood Center, Saitama 388,
2 Immunology Division, Jichi Medical School, Tochigi 329-04
and3 Institute of Immunology, Koraku 1-1-10, Bunkyo-ku, Tokyo 112, Japan
The genomic RNA of hepatitis C virus (HCV) in the plasma of volunteer blood donors was detected by using the polymerase chain reaction in a fraction of density 1·08 g/ml from sucrose density gradient equilibrium centrifugation. When the fraction was treated with the detergent NP40 and recentrifuged in sucrose, the HCV RNA banded at 1·25 g/ml. Assuming that NP40 removed a lipid-rich surface coat from HCV, the 1·08 g/ml and 1·25 g/ml HCV RNA may correspond to intact HCV virions and nucleocapsids, respectively. The extraordinarily low density of the virion is unusual in comparison to the density of classified viruses.
Received 13 August 1991;
accepted 19 November 1991.
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