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Early promoters of genital and cutaneous human papillomaviruses are differentially regulated by the bovine papillomavirus type 1 E2 gene product

Efrain Garrido-Guerrero^2,

Patricio Gariglio^2,>

¹ Departamento de Biología Molecular, Instituto de Investigaciones Biomédicas, UNAM, Apdo. Postal 70-228, 04510 México D.F.
and² Departamento de Genética y Biología Molecular, CINVESTAV-IPN Apdo. Postal 14-740, 07000 México D.F., Mexico

The physical state of the human papillomavirus (HPV) genome is usually different in malignant lesions of the skin, in which it is generally found in episomal form, and genital mucosa, in which it is frequently integrated with disruption of the E2 gene. Using chimeric or natural HPV promoters in the presence of the bovine papillomavirus type 1 E2 gene product, we observed transcription activation or repression, depending on the distance of E2-binding motifs from the start site. We found a clear difference in the positions of E2-binding motifs in cutaneous and genital HPVs that may partly explain the selective pressure for genome integration of genital HPV types in malignant lesions.

Present address: Laboratorio de Inmunología, UMF, ENEP-Iztacala UNAM, Mexico.

^> Present address: Departamento de Genética Microbiana, CISEI, INSP, Cuernavaca, Morelos, Mexico.

Received 11 November 1991; accepted 17 February 1992.

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